Is grapefruit juice a good fat burner?

Losing weight is a goal for many people. With the rise in obesity rates, finding ways to shed pounds and keep them off is more important than ever. Some claim that drinking grapefruit juice can help burn fat and promote weight loss. But does the science back up these claims? Let’s take a look.

How Grapefruit Juice May Help With Weight Loss

There are a few ways that grapefruit juice may support weight loss efforts:


Grapefruit contains an enzyme called AMP-activated protein kinase (AMPK). AMPK is sometimes called a “metabolic master switch” because it regulates metabolism and energy production. Increased AMPK activity may:
– Boost fat burning
– Reduce appetite
– Improve blood sugar control and insulin sensitivity


Grapefruit is rich in antioxidants and phytochemicals like naringenin and hesperidin. These plant compounds may:
– Reduce inflammation
– Improve insulin resistance
– Help prevent obesity and metabolic syndrome


Grapefruit is a good source of fiber. Getting enough fiber can:
– Curb appetite and promote feelings of fullness
– Slow digestion to stabilize blood sugar
– Feed beneficial gut bacteria linked to weight regulation

Does the Research Support Grapefruit Juice for Weight Loss?

Most of the evidence around grapefruit juice and weight loss comes from studies on an isolated compound found in grapefruit called naringin. Animal and some human studies suggest naringin may:

  • Suppress appetite
  • Increase calorie burn
  • Reduce fat formation
  • Regulate blood sugar

However, research looking specifically at grapefruit juice is more limited. Here’s a look at some key findings:

A 12-Week Study from 2014

In one study, 76 obese adults were randomized to drink 240 mL of grapefruit juice or a grapefruit flavored drink before meals for 12 weeks. Both groups also followed a calorie-restricted diet and exercise plan.

Results showed that the grapefruit juice group lost significantly more weight compared to the flavored drink group. On average, the grapefruit juice group lost 3.5 lbs (1.6 kg) more.

A 2006 Study on Body Fat and Inflammation

In another study, 32 obese adults drank 330 mL of grapefruit juice daily before a meal for 12 weeks. They also followed a weight loss diet but did not increase physical activity.

Those drinking the grapefruit juice had significantly greater reductions in weight and body fat compared to the control group drinking a placebo juice. Inflammatory markers like tumor necrosis factor alpha (TNF-α) also decreased.

A Smaller Study from 2011

A 2011 study in 17 obese individuals found drinking grapefruit juice before meals for 3 months resulted in an average weight loss of 1.6 kg (3.5 lbs). Participants also had decreased body fat and improved insulin resistance.

However, the study did not include a control group, making it difficult to say if grapefruit juice was directly responsible for the effects.

Overall, research suggests grapefruit juice may provide modest benefits for weight loss when paired with diet and exercise. However, larger and longer human studies are still needed.

Other Potential Benefits of Grapefruit Juice

In addition to potential fat burning properties, grapefruit juice provides a few other health perks:

Vitamins, Minerals and Antioxidants

Grapefruit juice is packed with important vitamins, minerals and plant compounds like:

  • Vitamin C
  • Potassium
  • Folate
  • Vitamin A
  • Bioflavonoids

These nutrients support immune function, heart health, skin health and more.

May Lower Cholesterol

Some research indicates grapefruit juice may lower LDL (bad) cholesterol and improve HDL (good) cholesterol due to its naringin content.

Vision Protection

The antioxidants in grapefruit, like vitamin C, beta-carotene and zeaxanthin, help protect vision from UV damage and may lower risks of macular degeneration.

Supports Hydration

Like other fruit juices, grapefruit juice provides fluid to help meet daily hydration needs.

Downsides of Grapefruit Juice

Despite the potential benefits, there are some downsides to drinking grapefruit juice as well:

High in Sugar

Grapefruit juice is relatively high in sugar, with about 20-25 grams per 8 oz (240 mL) serving. Even if it’s natural sugar, too much added sugar in your diet can increase diabetes and obesity risks.

May Interact With Medications

Grapefruit juice contains compounds that inhibit cytochrome P450, an enzyme involved in metabolizing many medications. Consuming grapefruit while taking certain prescriptions may cause high drug levels and side effects.

Some of the medications include:

  • Immunosuppressants
  • Benzodiazepines
  • Statins
  • Blood pressure medications
  • Antidepressants

Erodes Tooth Enamel

Like other acidic drinks, grapefruit juice can erode tooth enamel with frequent consumption. Diluting it with water and using a straw may help minimize contact with teeth.

Grapefruit Juice Dosage for Weight Loss

Based on the current research, about 8-12 ounces (240-350 mL) of grapefruit juice daily may provide benefits for weight loss. It’s best consumed before meals.

Drinking grapefruit juice in moderation as part of a balanced, calorie-controlled diet and active lifestyle is likely your best bet for weight management.

The Bottom Line

Research suggests grapefruit juice may modestly support weight loss through its beneficial plant compounds. It may also improve cholesterol, protect vision, stay hydrated and supply key nutrients.

However, grapefruit juice is high in sugar and can interact with numerous medications. Talk to your healthcare provider before adding it to your diet if you take any prescriptions.

For most people, enjoying grapefruit juice in moderation may be beneficial as part of an overall healthy lifestyle.

Frequently Asked Questions

How much grapefruit juice should you drink for weight loss?

Studies showing weight loss benefits used between 8-12 oz (240-350mL) of grapefruit juice per day, drunk before meals.

Is grapefruit juice good for belly fat?

Some research indicates grapefruit juice can help reduce overall body fat, including dangerous visceral belly fat. But results may be modest compared to lifestyle changes.

When should you drink grapefruit juice?

It’s best to drink grapefruit juice about 15-30 minutes before meals to take advantage of its appetite suppressing effects. Drinking it along with or after meals offers less benefit.

Does grapefruit juice make you poop?

Grapefruit juice contains fiber and water which can stimulate bowel movements. But effects may vary by individual.

Can I drink grapefruit juice at night?

It’s best to avoid grapefruit juice in the evenings since its high sugar content can provide energy right before bed. This can disrupt sleep quality.

Grapefruit Juice (8 oz) Calories Total Fat Sodium Total Carbs Sugar Protein
White 96 0g 2mg 22g 20g 2g
Pink or Red 96 0g 1mg 25g 23g 1g

As you can see, one 8 oz serving of grapefruit juice contains around 90-100 calories and 20-25 grams of natural sugar. It’s also low in fat and protein.

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