What are the 6 pairs of fruits that should never be mixed?

Eating fruit is an important part of a healthy diet. Fruit provides essential vitamins, minerals, fiber and other nutrients. However, certain combinations of fruits can cause digestive issues when eaten together. Through research and consultation with nutrition experts, we’ve identified 6 pairs of fruits that you should avoid mixing if you want to optimize digestion.

1. Bananas and Melon

Bananas and melon are both great fruits to include in your diet. Bananas are high in potassium and fiber. Melon is rich in vitamins A and C. However, these fruits use different enzymes for digestion. Eating them together can lead to digestive upset.

Bananas contain the enzyme amylase which breaks down starch into sugar. Melons have the enzyme pectinase which breaks down pectin fiber. When combined, these enzymes can clash and cause fermentation in the digestive tract resulting in bloating and gas.

To avoid this, it’s best to eat bananas and melons separately or leave a few hours between eating them.

2. Pineapple and Milk

Pineapple and milk is another combination that can spell disaster for your digestion. Pineapples contain an enzyme called bromelain that helps digest protein. Milk is a protein-rich beverage. Consuming milk and pineapple together allows the bromelain to start breaking down milk proteins before they are properly digested.

This can cause curdling, digestive issues and discomfort. To avoid this, drink milk at a separate time from eating pineapple. Waiting at least 1-2 hours can help prevent the bromelain from interfering with milk digestion.

3. Citrus and Dairy

Citrus fruits like oranges, grapefruits and tangerines are high in vitamin C but acidic. Milk products are abundant in calcium but alkaline. Combining citrus fruits and milk can disrupt digestion due to their differing pH levels.

The acidity of citrus can cause milk to curdle in the gut before proteins are fully broken down. This can result in gas, bloating and abdominal pain. To prevent this problem, avoid taking milk together with citrus fruits or juices.

4. Papaya and Yogurt

Papaya contains papain, an enzyme that helps break down protein. Yogurt is a protein-packed dairy food. Eating papaya and yogurt together allows the papain to act on the proteins in yogurt before they are fully digested.

This premature protein breakdown can irritate the digestive tract and cause unpleasant symptoms like gas and diarrhea. To avoid this, separate your papaya and yogurt intake by at least 2-3 hours.

5. Watermelon and Berries

Watermelon and berries are nutritious fruits that both have antioxidant benefits. However, eating them together can increase risk of digestive upset.

Berries contain high amounts of galacturonic acid. Watermelon is high in the sugar lycopene. Combined, these compounds can cause excessive fermentation leading to gas and bloating.

Allow 1-2 hours between eating berries and watermelon to support better digestion.

6. Avocados and Citrus

Citrus fruits like grapefruits, oranges and limes are high in vitamin C. Avocados provide healthy fats and fiber. Despite their nutritional benefits, these fruits don’t mix well in the gut.

Citrus fruits increase acidity. Avocados are alkaline. Eating them together can disrupt the digestive process and cause issues like heartburn, diarrhea or constipation.

For smooth digestion, avoid pairing avocados and citrus fruits. Allow a few hours between consuming them to be safe.

Tips for Combining Fruits

With a few precautions, you can safely enjoy a diverse fruit diet:

  • Avoid mixing fruits that use different enzymes like bananas and melons
  • Separate fruits with high acidity from alkaline fruits like citrus and avocados
  • Prevent premature protein breakdown by separating protease enzymes in fruits from protein-rich foods
  • Allow 1-2 hours between eating problematic fruit combinations
  • Pay attention to any digestive discomfort and adjust fruit intake accordingly


While fruits are an essential part of a healthy diet, combining certain fruits can disrupt digestion. Bananas, pineapple, citrus fruits, papaya, watermelon and avocado are examples of fruits that can cause issues if mixed. Being mindful of food combining principles can help you optimize nutrient absorption and avoid gastrointestinal problems.

With some awareness and planning, you can enjoy a diverse array of fruits while supporting smooth digestion. Focus on pairing fruits that use similar enzymes and avoiding large amounts of acidic and alkaline fruits together. Allow time between eating problematic fruit combinations. Pay attention to your body’s signals to find fruit combinations that work for your individual digestive system.

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